| 3/10/20 | Bradford (Park Avenue) |  | 1-3 |  | Spennymoor | Emirates FA Cup Second Round Qualifying | Horsfall Stadium |
| 6/10/20 | Spennymoor | | 2-1 |  | Farsley Celtic | National League North | The Brewery Field |
| 10/10/20 | Alfreton |  | 1-1 | | Spennymoor | National League North | The Impact Arena |
| 13/10/20 | Chester |  | 3-1 | | Spennymoor | Emirates FA Third Round Qualifying | Swansway Chester Stadium |
| 17/10/20 | Spennymoor | | 2-1 | | Chester | National League North | The Brewery Field |
| 7/11/20 | Spennymoor | | 2-2 |  | Gloucester | National League North | The Brewery Field |
| 10/11/20 | AFC Fylde |  | 1-0 | | Spennymoor | National League North | Mill Farm |
| 14/11/20 | Southport |  | 0-2 | | Spennymoor | National League North | Merseyrail Community Stadium |
| 28/11/20 | Spennymoor | | 2-2 | | Bradford (Park Avenue) | National League North | The Brewery Field |
| 1/12/20 | Spennymoor | | 0-2 |  | Guiseley | National League North | The Brewery Field |
| 5/12/20 | Spennymoor | | 3-1 |  | Curzon Ashton | National League North | The Brewery Field |
| 8/12/20 | Brackley Town |  | 1-0 | | Spennymoor | National League North | St James Park |
| 12/12/20 | York City |  | 1-1 | | Spennymoor | National League North | Bootham Crescent |
| 15/12/20 | Spennymoor | | 6-2 |  | Marske United | FA Trophy Second Round | The Brewery Field |
| 18/12/20 | Spennymoor | | 2-2 (4-5 on pens) | | Southport | FA Trophy Third Round | The Brewery Field |
| 26/12/20 | Darlington |  | 0-0 | | Spennymoor | National League North | Blackwell Meadows |
| 28/12/20 | Gateshead |  | 1-3 | | Spennymoor | National League North | Gateshead International Stadium |
| 9/2/21 | Chorley |  | Postponed | | Spennymoor | National League North | Victory Park |
| 13/2/21 | Spennymoor | | Postponed | | Alfreton | National League North | The Brewery Field |
| 20/2/21 | Farsley Celtic | | Postponed | | Spennymoor | National League North | The Citadel |
| 23/2/21 | Spennymoor | | Postponed | | Darlington | National League North | The Brewery Field |
| 27/2/21 | Spennymoor | | Postponed | | Brackley | National League North | The Brewery Field |
| 6/3/21 | Chester | | Postponed | | Spennymoor | National League North | Swansway Chester Stadium |
| 13/3/21 | Spennymoor | | Postponed | | AFC Fylde | National League North | The Brewery Field |
| 20/3/21 | Gloucester | | Postponed | | Spennymoor | National League North | New Meadow Park |
| 23/3/21 | Blyth |  | Postponed | | Spennymoor | National League North | Croft Park |
| 27/3/21 | Spennymoor | | Postponed | | Southport | National League North | The Brewery Field |
| 2/4/21 | Spennymoor | | Postponed |  | Boston United | National League North | The Brewery Field |
| 5/4/21 | Bradford (Park Avenue) | | Postponed | | Spennymoor | National League North | Horsfall Stadium |
| 10/4/21 | Spennymoor | | Postponed | | York City | National League North | The Brewery Field |
| 13/4/21 | Guiseley | | Postponed | | Spennymoor | National League North | Nethermoor Park |
| 17/4/21 | Hereford |  | Postponed | | Spennymoor | National League North | Edgar Street |
| 24/4/21 | Spennymoor | | Postponed | | Chorley | National League North | The Brewery Field |
| 1/5/21 | Spennymoor | | Postponed | | Gateshead | National League North | The Brewery Field |
| 3/5/21 | Leamington |  | Postponed | | Spennymoor | National League North | Phillips 66 Community Stadium |
| 8/5/21 | Spennymoor | | Postponed |  | Kidderminster | National League North | The Brewery Field |
| 15/5/21 | Curzon Ashton | | Postponed | | Spennymoor | National League North | Tameside Stadium |
| 22/5/21 | Kettering Town |  | Postponed | | Spennymoor | National League North | Latimer Park |
| 29/5/21 | Spennymoor | | Postponed |  | AFC Telford | National League North | The Brewery Field |
